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Radiation Prevention
A form of phytic acid (Phytochemicals) plus an additional molecule inositol are
verifying the enhancing properties available in food and supplements in
preventing cell damage from nuclear free radicals. Wheat bran and
flaxseed have up to 3% phytic acid, (watch out for gluten sensitivity).
See link with 65 herbs, fruits, medicinal plants, and beans that contain phytochemicals.
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Antioxidants Could Provide All-purpose Radiation Protection
05 November 2007 - sciencedaily.com
ScienceDaily (Nov. 5, 2007) — Two common dietary
molecules found in legumes and bran could protect DNA
from the harmful effects of radiation, researchers from the University
of Maryland report. Inositol and inositol hexaphosphate (IP6)
protected both human skin cells and a skin cancer-prone mouse from
exposure to ultraviolet B (UVB) radiation, the damaging radiation
found in sunlight, the team reported November 5 at the American
Association for Cancer Research Centennial Conference on Translational
Cancer Medicine.
According to the researchers, inositol and IP6 could decrease the
severity of side effects from radiation therapy, saving healthy cells
while simultaneously increasing the potency of the treatment against
cancer cells. Both molecules are potent antioxidants, the Maryland
researchers say, capable of preventing reactive molecules from
injuring DNA and turning cells cancerous.
"Both of these potent antioxidants have been shown to have
broad-spectrum anti-tumor capabilities, and now our studies confirm
the degree to which these molecules protect against the DNA-damaging
effects of ionizing radiation," said Abulkalam M. Shamsuddin, M.D.,
professor of pathology at the University of Maryland School of
Medicine. "Radiation damage is radiation damage, regardless of the
source, so there could also be a protective role for IP6 in any form
of radiation exposure, whether it is from a therapeutic dose or from
solar, cosmic or nuclear sources."
While both inositol and IP6 are related to B vitamins, they are not
considered essential dietary nutrients. In the 1980s, however,
researchers discovered that these molecules, abundant within the
hulls of seeds and grains, had definitive protective effects
against colorectal cancer.
Inspired by reports of a clinical trial begun in 2001 at Clinical
Hospital in Split, Croatia, which suggested IP6 enhanced the
effectiveness of radiotherapy while lessening the side effects,
Shamsuddin and his colleagues sought to investigate the extent of the
protective properties of these molecules. With funding from IP-6
Research, Inc., a company formed by Shamsuddin, the researchers began
a study to determine how human skin cells responded to UVB radiation
when dosed with IP6.
Normally, cells permanently damaged by radiation undergo a genetically
programmed process of cell suicide, called apoptosis. Shamsuddin
reports that UVB-irradiated human keratinocytes, when treated with
IP6, were more likely to survive. Untreated skin cells were more
likely to undergo apoptosis, indicating that the DNA in those cells
was damaged irreparably and fatally. According to Shamsuddin, the
treated cells take an extended pause at the point in the cellular life
cycle where innate mechanisms repair DNA before the cell divides.
"IP6 certainly has some interactivity with DNA, but how exactly it
works to repair DNA is still something of a mystery. There are reports
that IP6 binds with DNA repair molecule Ku to bring about the repair
process," Shamsuddin said. "More importantly, we still don't know how
IP6 can appear to help healthy cells live while also enhancing the
ability of radiation to kill cancer cells."
Shamsuddin and his team found that when mice engineered to be prone to
skin cancer were given drinking water containing a two-percent
solution of IP6, they were much less likely to develop tumors.
Twenty-three percent of treated mice developed tumors, compared to 51
percent of untreated, or control mice, which developed tumors.
Moreover, the mice in the treated group that did develop cancer had
only half as many tumors as the control mice.
Similarly, Shamsuddin saw that mice treated with a topical cream
containing four percent IP6 plus one percent inositol were also less
likely to develop tumors. When they administered the cream an hour
before UVB irradiation akin to sun exposure, 62 percent of the treated
mice developed tumors compared to 76 percent of the control mice.
According to Shamsuddin, their findings indicate that either topical
or ingested IP6 might confer protection against ionizing radiation.
Ionizing radiation occurs in the environment in many forms,
originating from both natural and human-contrived sources. In humans,
exposure to ionizing radiation occurs primarily through therapeutic
techniques (such as anticancer radiotherapy), and sunbathing.
Astronauts, pilots and passengers of high-altitude aircraft also are
inordinately exposed to solar radiation. Such radiation exposures have
a cumulative effect, increasing the chances of developing cancer over
time, researchers say. "It is possible that people regularly exposed
to ionizing radiation, such as airline pilots, frequent fliers or
people who handle radioactive materials, might take IP6
prophylactically to prevent possible long term effects of exposure,"
Shamsuddin said.
According to Shamsuddin, IP6 could also offer protection against
accidents or purposeful incidents involving nuclear material. "It
could also be advisable to use IP6 plus inositol as a cautionary
treatment following a nuclear disaster or dirty bomb," Shamsuddin
said.
Adapted from materials provided by American Association for Cancer
Research.
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Reference:
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Phytochemical Plant List |
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Phytochemicals: A New Paradigm (Hardcover) |
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Messages From Earth |
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